| 摘要 |
<p>Provided are 3-fluoroalkyl-1-substituted pyrazole-4-carboxylic acid and a preparation method therefor. In the method, a fluoroacetic acid derivative, as a starting material, is condensed with an acetamide derivative to form a fluoroacetoacetamide derivative, followed by reacting with an orthoformate to form a 2-alkoxymethylenefluoroacylacetamide derivative, and then reacting with a hydrazine reagent to obtain a 1-substituted-3-fluoroalkylpyrazole-4-amide derivative, which is hydrolysed to obtain 3-fluoroalkyl-1-substituted pyrazole-4-carboxylic acid. The method uses cheap and easily available starting materials, is simple to operate, has low equipment requirements, and is suitable for large-scale industrial production.</p> |
