SYSTEM FOR DELIVERY INTO XCR1 POSITIVE CELL AND USES THEREOF

摘要

PROBLEM TO BE SOLVED: To provide a delivery system suitable for delivering a substance into a chemokine (C motif) receptor 1 (XCR1) positive professional antigen-presenting cell.SOLUTION: A delivery system comprises (1) a molecule binding to XCR1 and (2) a substance to be delivered, wherein the substance is bound to the molecule. In the delivery system, the substance to be delivered is an immunogen, an adjuvant, a drug, or a toxic agent, and the molecule binding to XCR1 is chemokine (C motif) ligand 1 (XCL1) or a functionally active variant thereof. In the delivery system, the immunogen is a pathogen, a pathogen-derived antigen, an allergen, a tumor antigen or a tolerogen, and a toxic agent is a cytotoxin, apoptosis-inducing agents, ribosome-inactivating agents, DNA-cleaving agent, RNA-cleaving agent, or inhibitors of protein synthesis.