REGULATION OF GLUCOSE METABOLISM USING ANTI-CGRP ANTIBODIES

摘要

The present disclosure provides methods for the prevention or treatment of metabolic disorders. In exemplary embodiments, methods of administering an anti-CGRP antibody are provided, optionally in combination with a second agent, wherein peripheral and/or hepatic glucose utilization is increased, thereby preventing or treating diseases and disorders associated with insulin resistance. Compositions comprising an anti-CGRP antibody are also provided, optionally in combination with a second agent, which are suitable for administration to increase peripheral and/or hepatic glucose utilization and thereby prevent or treat diseases and disorders associated with insulin resistance.

主权项

1. A method of (i) increasing peripheral and/or hepatic glucose utilization, (ii) decreasing insulin resistance, (iii) preventing or controlling obesity, achieving sustained normoglycemia, and/or (v) increasing the ratio of lean tissue to body fat in a subject in need thereof, comprising administering an effective amount of a composition comprising an anti-human CGRP antibody or antibody fragment to said subject.