发明名称 |
SIZE-BASED ANALYSIS OF FETAL DNA FRACTION IN MATERNAL PLASMA |
摘要 |
<p>A method of analyzing a biological sample of an organism, the biological sample including DNA originating from normal cells and potentially from cells associated with cancer, wherein at least some of the DNA is cell-free in the biological sample, the method comprising: for each size of a plurality of sizes: measuring an amount of a first set of DNA fragments from the biological sample corresponding to the size; calculating a first value of a first parameter based on the amounts of DNA fragments at multiple sizes, the first parameter providing a statistical measure of a size profile of DNA fragments in the biological sample; comparing the first value to a reference value; and determining a classification of a level of cancer in the organism based on the comparison.</p> |
申请公布号 |
EP2823062(A1) |
申请公布日期 |
2015.01.14 |
申请号 |
EP20130757943 |
申请日期 |
2013.03.08 |
申请人 |
THE CHINESE UNIVERSITY OF HONG KONG |
发明人 |
LO, YUK MING DENNIS;CHAN, KWAN CHEE;ZHENG, WENLI;JIANG, PEIYONG;LIAO, JIAWEI;CHIU, WAI KWUN ROSSA |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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