发明名称 |
METHOD FOR STIMULATING T CELL AND USE THEREOF |
摘要 |
<p>An object of the present invention is to stimulate a T cell without using a peptide/MHC tetramer. In the present invention, the step of supplying an antigen peptide to a T cell having a T cell receptor (TCR) that can recognize the antigen peptide on cell surface to form a complex of a major histocompatibility complex (MHC) molecule on the cell surface of the T cell and the antigen peptide is used, and the T cell is stimulated through recognition by TCR of the antigen peptide as the MHC molecule-antigen peptide complex on the cell surface of the same T cell. Such a stimulating and activating method would be applicable to not only T cells, but also various cells. According to the present invention, an antigen-specific T cell can be identified without establishing any antigen-specific T cell strain, and without using such a reagent as MHC/peptide tetramer. That is, a cancer-specific T cell can be efficiently and conveniently identified.</p> |
申请公布号 |
EP2824182(A1) |
申请公布日期 |
2015.01.14 |
申请号 |
EP20130758671 |
申请日期 |
2013.03.06 |
申请人 |
NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA |
发明人 |
KISHI, HIROYUKI;MURAGUCHI, ATSUSHI;HAMANA, HIROSHI;KOBAYASHI, EIJI;OZAWA, TATSUHIKO |
分类号 |
C12N15/09;A61K39/00;A61K47/42;C12N5/0783;C12N5/10;C12Q1/02;G01N33/53;G01N37/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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