发明名称 |
Process for the preparation of simvastatin from lovastatin or mevinolinic acid |
摘要 |
<p>A process for preparing simvastatin from lovastatin or mevinolinic acid in salt form comprises treating either starting material with cyclopropyl or butyl amide, the pyranone ring thereby being opened when lovastatin is the starting material, adding a methyl group to the 2-methylbutyrate side chain, and thereafter closing the open pyranone ring to produce simvastatin. The process is performed without protecting and deprotecting the two hydroxy groups of the open pyranone ring. In a preferred embodiment, the starting material is treated with cyclopropyl amine which produces simvastatin via the novel intermediate lovastatin cyclopropyl amide.</p> |
申请公布号 |
IN184969(B) |
申请公布日期 |
2000.10.14 |
申请号 |
IN1997DE17519 |
申请日期 |
1997.01.24 |
申请人 |
RANBAXY LABORATORIES LIMITED |
发明人 |
KUMAR YATINDRA;THAPER RAJESH KUMAR;MISRA SATYA NAND;KUMAR, S. M., DILEEP;KHANNA JAG MOHAN |
分类号 |
C07C231/14;C07D311/92;(IPC1-7):C07D311/92 |
主分类号 |
C07C231/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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