| 发明名称 | HIV VPR-specific T cell receptors | ||
| 摘要 | The instant invention provides TCRs having one or more amino acid substitutions that bind to the AL9 epitope of the HIV protein vpr (AIIRILQQL (SEQ ID NO: 1)). | ||
| 申请公布号 | US8933198(B2) | 申请公布日期 | 2015.01.13 |
| 申请号 | US201012731485 | 申请日期 | 2010.03.25 |
| 申请人 | Altor BioScience Corporation | 发明人 | Fernandez Marilyn;Liu Bai;Marcus Warren D.;Wong Hing C. |
| 分类号 | C07K1/00;G01N33/569;C07K14/725;C07K14/705 | 主分类号 | C07K1/00 |
| 代理机构 | Edwards Wildman Palmer LLP | 代理人 | Edwards Wildman Palmer LLP ;Corless Peter F. |
| 主权项 | 1. An isolated T cell receptor (TCR) that specifically binds an HIV Vpr epitope, wherein said HIV Vpr epitope comprises a peptide sequence selected from the group consisting of AIIRILQQL (SEQ ID NO: 1) and SEQ ID NOs: 31-44, and wherein the isolated T cell receptor comprises a Y93H or S39P mutation in the TCR Vα chain of the polypeptide set forth in SEQ ID NO: 3. | ||
| 地址 | Miramar FL US | ||