发明名称 |
HUMANE ANTISTOFFER MOD HUMAN CD20 OG FREMGANGSMÅDE TIL ANVENDELSE DERAF |
摘要 |
A human antibody or antigen-binding fragment of an antibody that specifically binds human CD20 and is capable of inducing complement dependent cytotoxicity (CDC), and is capable of increasing symptom free survival time between about 2-fold to about 9-fold or more, relative to control-treated animals in a mouse model of human lymphoma. The antibody or antigen-binding fragment thereof is useful in a therapeutic method for treating a CD20-mediated disease or condition, such as for example, non-Hodgkin's lymphoma, rheumatoid arthritis, systemic lupus erythematosus, Crohn's disease, chronic lymphocytic leukemia, and inflammatory diseases. |
申请公布号 |
DK2178916(T3) |
申请公布日期 |
2015.01.12 |
申请号 |
DK20080796917T |
申请日期 |
2008.07.31 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
ALLISON, ERIN, M.;MARTIN, JOEL, H.;WANG, LI-HSIEN;STEVENS, SEAN |
分类号 |
C07K16/28;A61K39/395;A61P35/00 |
主分类号 |
C07K16/28 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|