GENERATION OF REAGENT IONS FOR ION-ION REACTIONS

摘要

An apparatus, system and method of providing that allow for the generation of reagent ions within an inner region of a mass spectrometer for use in ion-ion reactions such as PTRs and ETD using a reagent ion generator. The location where these reagent ions are generated can be as close as possible to the point of action, or the reaction zone where the reagent ion and analyte ions will interact via ion-ion reactions to cause, e.g., PTRs and/or ETD.

主权项

1. A mass spectrometer system, comprising:
a first chamber, a reagent ion generator coupled to said first chamber, said ion generator comprising:
a hollow conduit extending from a proximal end to a distal end, wherein said proximal end is adapted for introducing reagent molecules from a source into said conduit and said distal end is disposed inside said first chamber, andan electrically conducting wire disposed at least partially within said hollow conduit and extending from a proximal portion to a distal tip portion, wherein said distal tip portion is positioned in proximity to said distal end of the conduit, anda voltage source adapted for electrically coupling to a portion of the wire for applying a voltage to said wire sufficient for causing an electric discharge in proximity of said distal tip portion of the wire.