发明名称 PYRROLOPYRAZONE INHIBITORS OF TANKYRASE
摘要 There are provided compounds of the formula;;wherein R1 and R2 are as described herein. The compounds are useful as anticancer agents.
申请公布号 US2015011556(A1) 申请公布日期 2015.01.08
申请号 US201414492460 申请日期 2014.09.22
申请人 HOFFMANN-LA ROCHE INC. 发明人 Hermann Johannes;Petersen Ann Catherine;Wanner Jutta;Yi Lin
分类号 C07D487/04 主分类号 C07D487/04
代理机构 代理人
主权项 1. A compound of the formula wherein R1 is selected from the group consisting of C1-6 alkyl, halo, cyano, C1-6 hydroxyalkyl, R2 is (i)aryl (ii)heteroaryl said aryl or heteroaryl optionally substituted by one or three groups independently selected from C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl or halogen and said heteroaryl is pyridinyl, (iii) piperazinyl or (iv) piperidinyl said piperazinyl or piperidinyl optionally substituted by aryl which aryl is optionally substituted as described above; or, a pharmaceutically acceptable salt thereof.
地址 Little Falls NJ US