IONIZATION WITH FEMTOSECOND LASERS AT ELEVATED PRESSURE

摘要

The present disclosure generally provides ionization methods and devices for use in mass spectrometry. In some embodiments, the ionization methods and devices employ short laser pulses (e.g., pulses having pulsewidths in a range of about 2 fs to about 1 ps) at a high intensity (e.g., an intensity in a range of about 1 TW/cm2 to about 1000 TW/cm2) to ionize an analyte an ambient pressure greater than about 10−5 Torr (e.g., an ambient pressure in a range of about 1 atmosphere to about 100 atmospheres).

主权项

1. In a mass spectrometer, a method for ionizing a sample, comprising:
irradiating a sample at an ambient pressure in a range of about 10−5 Torr to about 105 Torr with one or more radiation pulses having a pulsewidth in a range of about 2 fs to about 1 ps at a pulse power density in a range of about 1 TW/cm2 to about 1000 TW/cm2 to cause ionization of at least a portion of the sample.