NOVEL DROSOPHILA TUMOR MODEL FOR SCREENING ANTI-CANCER DRUGS AND METHODS THEREOF

摘要

A novel Drosophila tumor model capable of screening target specific anti-cancer compounds. Tumorous growths in larval lymph organ and presumptive adult somatic epithelia are induced by aberration/mis-regulation of specific cellular pathways, caused by loss of a tumor suppressor gene, such as scribble. Tumorous growths are thereafter suppressed either by genetic manipulations or by exposure to anti-cancer compounds by blocking, down-regulating or compromising said aberrant signalling pathway. Methods for obtaining said novel Drosophila tumor model are also provided.