发明名称 |
REGENERATION OF ISLET BETA CELLS BY HSP60 DERIVED PEPTIDES |
摘要 |
The present invention provides compositions for use in the treatment of long-established type 1 diabetes (T1D) using peptides and analogs of heat shock protein 60 (Hsp60). The invention is exemplified using DiaPep277, a peptide analog of human Hsp60, which is shown to induce increase in plasma C-peptide and regeneration of islet beta cells. The invention further relates to regimens useful for treatment of long established T1D in patients having no demonstrable islet beta cell-function. |
申请公布号 |
US2015011471(A1) |
申请公布日期 |
2015.01.08 |
申请号 |
US201314379772 |
申请日期 |
2013.02.28 |
申请人 |
Yeda Research and Development Co. Ltd. |
发明人 |
Cohen Irun R.;Margalit Raanan |
分类号 |
A61K38/17 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Rehovot IL |