发明名称 FORMYLATED XANTHOCILLIN ANALOGUES AS NEUROPROTECTIVE AGENTS
摘要 Formylated xanthocillin analogs can be used in the treatment of neurodegenerative diseases. The analogs can be prepared synthetically, and at least some of the analogs can be obtained from a microorganism strain of the Penicillium chrysogenum species.
申请公布号 US2015011621(A1) 申请公布日期 2015.01.08
申请号 US201314377143 申请日期 2013.02.02
申请人 NEURON BIOPHARMA, S.A. 发明人 Ramos Martin Maria del Carmen;Campoy García Sonia;Burgos Muñoz Javier Santos;Adrio Fondevila José Luis;Velasco Alvarez Javier
分类号 C07D407/06;C07C233/25;C07C233/22 主分类号 C07D407/06
代理机构 代理人
主权项 1. A method of impeding or treating neurodegenerative diseases selected from Alzheimer's disease, mild cognitive impairment, Huntington's disease, Parkinson's disease, Creutzfeldt-Jakob disease, Alexander disease, cognitive and/or psychomotor deficits, ataxias, dementias, cerebrovascular diseases, amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS), as well as diseases associated with aging, pathological processes associated with age and progeria, which comprises the administration to a patient needing such treatment, of a therapeutically effective amount of at least a compound of formula (I): where: R1 is selected from alkyl, OH, O-alkyl, SH, S-alkyl, NH2, NH-alkyl, N(alkyl)2 and halogen, R2, R3 and R4 are selected independently from hydrogen, alkyl, OH, O-alkyl, SH, S-alkyl, NH2, NH-alkyl, N(alkyl)2 and halogen, or R1 and R2 and/or R3 and R4 form an —O-alkylene-O— group, or a pharmaceutically acceptable salt or solvate thereof.
地址 Granada ES