USE OF TRIFLUOROACETAMIDE FOR N-TERMINAL PROTECTION

摘要

This disclosure teaches the novel use of trifluoroacetamide for N-terminal protection. The disclosure also teaches novel compositions and chemical structures associated therewith. These methods and compositions are useful for site-specific methylation of peptide backbone amides, performed, for example, to modulate the pharmacokinetic properties of peptide drugs.

主权项

1. A method for solid phase peptide synthesis (SPPS) comprising N-terminal protection of an amino acid, the method comprising binding of trifluoroacetamide (Tfac) to the N-terminal of the amino acid.