| 主权项 |
1. A C5 binding polypeptide, comprising a C5 binding motif, BM, which motif consists of an amino acid sequence selected fromi)(SEQ ID NO: 763)EX2X3X4A X6X7EID X11LPNL X16X17X18QW X21AFIX25 X26LX28D, wherein, independently of each other,
X2 is selected from H, Q, S, T and V;X3 is selected from I, L, M and V;X4 is selected from A, D, E, H, K, L, N, Q, R, S, T and Y;X6 is selected from N and W;X7 is selected from A, D, E, H, N, Q, R, S and T;X11 is selected from A, E, G, H, K, L, Q, R, S, T and Y;X16 is selected from N and T;X17 is selected from I, L and V;X18 is selected from A, D, E, H, K, N, Q, R, S and T;X21 is selected from I, L and V;X25 is selected from D, E, G, H, N, S and T;X26 is selected from K and S;X28 is selected from A, D, E, H, N, Q, S, T and Y;and ii) an amino acid sequence which has at least 86% identity to the sequence defined in i), wherein the polypeptide binds to C5. |
