| 主权项 |
1. A method of preparing a radioiodinated compound, the method comprising:
contacting a precursor with a radioactive iodide and an oxidant to form a reaction mixture comprising a radioiodinated compound, unreacted precursor, and reaction byproducts; and contacting the reaction mixture with avidin or streptavidin; thereby separating the radioiodinated compound from the precursor and the reaction byproducts; wherein the precursor is a compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein:R1 is an aromatic or vinyl group capable of being substituted at an aromatic or vinylic carbon with iodide;R2 and R3 are each independently selected from R1; alkyl or alkoxyalkyl, each substituted with 0-4 R5 groups; or R2 and R3, along with the Sn atom to which they are attached, form a 3 to 8-membered ring that optionally includes one or more heteroatom selected from N, O, or S;Z is selected from —(C1-C4)alkylene-, —(C1-C4)alkylene-O—, arylene, heteroarylene, cycloalkylene or heterocycloalkylene, provided that m is at least 1 when Z is arylene or heteroarylene, and n=1 to 9, and provided that p=2-10 when Z is —(C1-C4)alkylene-O—;X is selected from —O— or —NR4—;R4 is selected from H or alkyl, wherein the alkyl is substituted with 0-4 R6 groups;each R5 is independently selected from —H, -halogen, —CN, —NO2, —NRaRb, —S(O)iRc, —C(═O)Rc, —C(═O)ORc, or —OC(═O)Rc;R6 is selected from —H, -halogen, —CN, —NO2, —NRaRb, —ORc, —S(O)iRc, —C(═O)Rc, —C(═O)ORc, or —OC(═O)Rc;Ra, Rb and Rc are each independently selected from —H or (C1-C6)alkyl;Y is selected from S, SO, SO2 or O;i is 0, 1, or 2; andm, n and p are each independently an integer from 0 to 10, wherein m+n+p≧1. |
