Purification method of aztreonam

摘要

It discloses a process for refining Aztreonam, comprising the steps of 1) treating Aztreonam material with an alkali metal alkoxylate or an alkali earth metal alkoxylate under heating in the presence of a suitable solvent or a mixture of solvents, followed by adjusting the pH value with a suitable acid and cooling down to precipitate Aztreonam, which provides a primary purified Aztreonam; 2) adsorbing Aztreonam with strongly basic ion exchange resin, followed by eluting the resin and collecting the eluate, to provide a secondary purified Aztreonam after concentration under reduced pressure; 3) adjusting the pH value with a suitable acid to allow crystallization, followed by centrifuging and washing the resultant crystals, to provide a tertiary purified Aztreonam after drying. The refined Aztreonam product has a purity of no less than 99.2%, mostly no less than 99.5%, with little residue on ignition and significantly low content of heavy metals.

主权项

1. A process for refining Aztreonam comprising the following steps:
1) treating a crude Aztreonam with an alkali metal alkoxylate or an alkali earth metal alkoxylate with heat in a suitable solvent or a mixture of solvents, then adjusting pH with a suitable acid and cooling to precipitate Aztreonam which yields a primary purified Aztreonam; 2) loading the primary purified Aztreonam into a strongly basic ion exchange resin, then eluting the resin and collecting eluate which is concentrated by a reduced pressure to yield a secondary purified Aztreonam; and 3) adjusting pH value with a suitable acid to allow crystallization, then centrifuging, washing and drying the resultant crystals to yield a tertiary purified Aztreonam.