Promoter for regeneration of tendon-bone junction tissue or ligament-bone junction tissue

摘要

An object of the present invention is to provide a drug for promoting the regeneration of tendon-bone junction tissue or ligament-bone junction tissue. The present invention relates to a promoter for regeneration of tendon-bone junction tissue or ligament-bone junction tissue including the following (1) or (2) as an active ingredient:
(1) the following (1-a), (1-b), or (1-c)
(1-a) HGF protein,(1-b) a partial peptide of HGF protein, the peptide having an effect of promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue,(1-c) a salt of (1-a) or (1-b);(2) DNA including the following (2-a), (2-b), or (2-c),
(2-a) DNA encoding HGF protein,(2-b) DNA encoding a partial peptide of HGF protein, the peptide having an effect of promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue,(2-c) DNA encoding a protein or a peptide, the protein or the peptide having an effect of promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue, and the DNA hybridizing with DNA comprising a base sequence complementary to (2-a) or (2-b) under a stringent condition.

主权项

1. A method for promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue consisting essentially of administering the following (1) or (2) to a patient with tendon-bone junction tissue injury or ligament-bone junction tissue injury:
(1) a Hepatocyte Growth Factor (HGF) protein having an amino acid sequence at least 95% homologous to the amino acid sequence represented by SEQ ID NO: 3, and having an effect of promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue, or (2) a formulation consisting of (1), and at least one member selected from the group consisting of aqueous solvent, tonicity agent, buffer solution, preservative, thickener, stabilizer, pH adjuster, solubilizing agent, oily solvent, propellant, and biodegradable polymer, wherein (1) or (2) is locally applied to an interface region where the bone is in contact with the tendon or ligament, or a space between the bone and the tendon or ligament.