| 发明名称 | Anti-CD38 antibodies | ||
| 摘要 | Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies. | ||
| 申请公布号 | US8926969(B2) | 申请公布日期 | 2015.01.06 |
| 申请号 | US201213720837 | 申请日期 | 2012.12.19 |
| 申请人 | Takeda Pharmaceutical Company Limited | 发明人 | Elias Kathleen Ann;Landes Gregory;Singh Shewta;Korver Wouter;Drake Andrew Walling;Haak-Frendscho Mary;Snell Gyorgy Pal;Bhaskar Vinay |
| 分类号 | C07K16/28;C07K16/40;A61K39/395;C12N9/99;A61K39/00 | 主分类号 | C07K16/28 |
| 代理机构 | Morgan, Lewis & Bockius LLP | 代理人 | Morgan, Lewis & Bockius LLP |
| 主权项 | 1. A method of inhibiting the growth of the cell expressing a human CD38 protein (SEQ ID NO: 1) by contacting said cell with an antibody, wherein said antibody specifically binds human CD38 (SEQ ID NO:1) and cynomolgus CD38 SEQ ID NO:2) and comprises: a) a heavy chain variable region comprising: i) a first CDR comprising SEQ ID NO:3;ii) a second CDR comprising SEQ ID NO:4;iii) a third CDR comprising SEQ ID NO:5; and b) a light chain variable region comprising: i) a first CDR comprising SEQ ID NO:6;ii) a second CDR comprising SEQ ID NO:7;iii) a third CDR comprising SEQ ID NO:8. | ||
| 地址 | Osaka-shi JP | ||