Pyrimidine derivatives

摘要

The invention provides novel pyrimidine derivatives of formula I, to methods of preparing such compounds, to pharmaceutical compositions containing such compounds, and to methods for using such compounds in treatment of diseases including cancer; wherein R1, R2, R3, R4, R5, L, A, D, E, Z, and Y are as defined in the specification.;

主权项

1. A compound of formula I or a pharmaceutically acceptable solvate or salt thereof, wherein Z represents carbon or nitrogen; Y represents carbon or nitrogen, wherein one of Z and Y represents nitrogen and the other is carbon; A, D and E is selected from carbon or nitrogen, wherein A and D represent nitrogen and E represents carbon; or A and E represent nitrogen and D represents carbon; or E represents nitrogen and A and D represent carbon; L represents a bond or (C1-C2)alkyl; R1 represents hydrogen or methyl, when D represents carbon; R2 represents hydrogen or amino, when Y or Z represents carbon; R3 represents hydrogen, (C1-C3)alkyl, amino, trifluoromethyl or (C0-C1)alkylaryl; R4 represents heteroaryl, optionally substituted with one or more substituents; and R5 represents hydrogen or methyl; wherein when D represents nitrogen, R1 is absent, and when Z or Y, respectively, represents nitrogen, R2 is absent, and when E is nitrogen, L represents a bond or C2 alkyl.