发明名称 Thio compounds
摘要 A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of:; wherein A, B and D are each oxygen or sulfur, provided that least one of A, B and D is sulfur; and R1-R8 are each independently hydrogen, hydroxyl, acyl, substituted acyl, acyloxy, substituted acyloxy, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, aryl, substituted aryl, amino, substituted amino, halogen, heterocycloalkyl, substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, or a thio-containing group.
申请公布号 US8927725(B2) 申请公布日期 2015.01.06
申请号 US201113310242 申请日期 2011.12.02
申请人 The United States of America, as represented by the Secretary, Department of Health and Human Services 发明人 Greig Nigel H.;Luo Weiming;Tweedie David;Holloway Harold W.;Yu Qian-Sheng;Goetzl Edward J.
分类号 C07D401/00;A61K31/44 主分类号 C07D401/00
代理机构 Klarquist Sparkman, LLP 代理人 Klarquist Sparkman, LLP
主权项 1. A compound, or a pharmaceutically acceptable salt thereof, having a structure of:wherein A, B, D and E are each oxygen or sulfur, and R2-R4 and R6-R8 are each independently hydrogen, hydroxyl, acyl, substituted acyl, acyloxy, substituted acyloxy, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, aryl, substituted aryl, amino, substituted amino, halogen, heterocycloalkyl, substituted heterocycloalkyl, heteroaryl, substituted heteroaryl, or a thio-containing group, provided that A and B are sulfur, and D and E are oxygen, or A and D are sulfur, and B and E are oxygen, or B and E are sulfur, and A and D are oxygen, or D and E are sulfur, and A and B are oxygen.
地址 Washington DC US