| 发明名称 |
APTAMER WHICH SELECTIVELY BINDS TO ERBB2 RECEPTOR AND USES THEREOF |
| 摘要 |
Disclosed are a DNA aptamer specifically binding to the Her2 (ERBB2) receptor involved in the onset of breast cancer, a composition for the suppression of cancer metastasis comprising the same as an active ingredient, and a composition for the diagnosis of cancer comprising the same as an active ingredient. Due to its binding mechanism being different from that of the conventional antibody, the aptamer can be effectively used for suppressing cancer metastasis and diagnosing cancer. |
| 申请公布号 |
US2015005368(A1) |
申请公布日期 |
2015.01.01 |
| 申请号 |
US201114128152 |
申请日期 |
2011.08.10 |
| 申请人 |
Lee Jung Hwan;Chae Young Chan;Kim Youndong;Kang Hyungu;Im Jong Hun;Kim Jong In;Kim Ki Seok;Jang Sung Key;Oh II Ung;Choi Min Jeong;Kang Won Jun |
发明人 |
Lee Jung Hwan;Chae Young Chan;Kim Youndong;Kang Hyungu;Im Jong Hun;Kim Jong In;Kim Ki Seok;Jang Sung Key;Oh II Ung;Choi Min Jeong;Kang Won Jun |
| 分类号 |
C12N15/115;G01N33/574 |
主分类号 |
C12N15/115 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An ERBB2 aptamer, which specifically binds to ERBB2, and comprises a total of 20 to 100 nucleotides comprising 5 to 15 modified nucleotides, wherein the modified nucleotide is modified deoxyuracil (dUTP) and the position 5′ of the modified dUTP is substituted with a hydrophobic group selected from the group consisting of a naphthyl group, a benzyl group, a pyrrolebenzyl group, and tryptophan. |
| 地址 |
Pohang-si KR |
