BIOLOGICAL MARKER FOR EARLY CANCER DETECTION AND METHODS FOR CANCER DETECTION (BF819)

摘要

BF819 is a biomarker for the early detection of cancer. The natural polypeptide sequence of BF819 is disclosed along with the sequence of an epitope bound by a novel mAb BF819 used in tests and methods for cancer detection. Specific cancer and tumor types are identified where BF819 is overexpressed along with data showing the extent of the detection of BF819 in cancer, normal, and benign conditions.

主权项

1. A method of detecting an indicator of cancer in a patient comprising:
assayinq a patient test sample with a monoclonal antibody specific for CTD nuclear envelope phosphatase 1 under conditions permitting a binding reaction between the CTD nuclear envelope phosphatase 1 and the monoclonal antibody wherein the presence of CTD nuclear envelope phosphatase 1 at an elevated level in comparison to a normal level from a patient with no detectable cancer indicates the presence and/or extent of cancer, wherein the, and assayed CTD nuclear envelope phosphatase 1 is secreted in the patient test sample and identifying a tissue or organ as a source of secreted CTD nuclear envelope phosphatase 1, wherein the tissue or organ is selected from the group consisting of colon, prostate, pancreas and combinations thereof.