| 发明名称 |
Tris(hydroxymethyl)Aminomethane Salts of a Small-Molecule GLP1R Agonist and Pharmaceutical Compositions and Uses Thereof |
| 摘要 |
The invention provides tris(hydroxymethyl)aminomethane salts of a small-molecule GLP1R agonist. The invention further provides solid compositions comprising tris(hydroxymethyl)aminomethane salts of a small-molecule GLP1R agonist. The invention further provides uses of tris(hydroxymethyl)aminomethane salts of a small-molecule GLP1R agonist, e.g., for treating type 1 diabetes, type 2 diabetes, or obesity. |
| 申请公布号 |
US2015005339(A1) |
申请公布日期 |
2015.01.01 |
| 申请号 |
US201414489890 |
申请日期 |
2014.09.18 |
| 申请人 |
TransTech Pharma, LLC |
发明人 |
Almariego Danilo;Polisetti Dharma Rao;Benjamin Eric;El Abdellaoui Hassan;Sahoo Soumya P. |
| 分类号 |
A61K31/4375;B01J2/02 |
主分类号 |
A61K31/4375 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A tris(hydroxymethyl)aminomethane salt of (S)-3-(4′-cyano-biphenyl-4-yl)-2- {[(3R,7S)-3-[4-(3,4-dichloro-benzyloxy)-phenyl]-1-ethyl-2-oxo-6-((S)-1-phenyl-propyl)-2,3,5,6,7,8-hexahydro-1H-4-oxa-1,6-diaza-anthracene-7-carbonyl]-amino}-propionic acid. |
| 地址 |
High Point NC US |
