METHOD FOR MANUFACTURING A SHAPED CROSS-LINKED HYALURONIC ACID PRODUCT

摘要

A method for manufacturing a shaped cross-linked hyaluronic acid product is comprising the step of subjecting a non-cross-linked precipitated hyaluronic acid substrate in a desired shape to a single cross-linking reaction in a liquid mediumhaving a pH of 11.5 or higher and comprising one or more polyfunctional cross-linking agent(s) and anamount of one or more organic solvent(s) giving precipitating conditions for hyaluronic acid, under suitable conditions to obtain aprecipitated, shaped cross-linked hyaluronic acid product having a degree of modification of 1-40 cross-linking agent units per 1000 disaccharide units.