发明名称 |
COMPOSITIONS AND METHODS FOR GENERATING A PERSISTING POPULATION OF T CELLS USEFUL FOR THE TREATMENT OF CANCER |
摘要 |
The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is ligand independent and independent of the addition of exogenous cytokines or feeder cells. |
申请公布号 |
EP2817318(A1) |
申请公布日期 |
2014.12.31 |
申请号 |
EP20130751162 |
申请日期 |
2013.02.22 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
FRIGAULT, MATTHEW J.;ZHAO, YANGBING;SCHOLLER, JOHN;JUNE, CARL, H. |
分类号 |
C07H21/04;A01N63/00;A61K48/00;C07K14/705;C07K14/725;C07K16/18;C12N5/0783 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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