BIOMARKERS FOR COGNITIVE DYSFUNCTION DISEASES AND METHOD FOR DETECTING COGNITIVE DYSFUNCTION DISEASE USING BIOMARKERS

摘要

Provided are biomarkers for detecting cognitive dysfunction diseases and a method for detecting a cognitive dysfunction disease using the biomarker(s). The method for detecting a cognitive dysfunction disease which comprises simultaneously or separately measuring one or more kinds of biomarkers for detecting cognitive dysfunction diseases, said biomarkers being selected from (a), (b) and (c), in a biological sample: (a) a biomarker for detecting cognitive dysfunction diseases that comprises an intact protein of apolipoprotein A1 containing the amino acid sequence represented by SEQ ID NO:1 or a partial peptide thereof; (b) a biomarker for detecting cognitive dysfunction diseases that comprises an intact protein of transthyretin containing the amino acid sequence represented by SEQ ID NO:2 or a partial peptide thereof; and (c) a biomarker for detecting cognitive dysfunction diseases that comprises an intact protein of complement C3 containing the amino acid sequence represented by SEQ ID NO:3 or a partial peptide thereof.