发明名称 |
Targeting poly-gamma-glutamic acid to treat <i>Staphylococcus epidermidis </i>and related infections |
摘要 |
Immunogenic compositions and methods for eliciting an immune response against S. epidermidis and other related staphylococci are provided. The immunogenic compositions can include immunogenic conjugates of poly-γ-glutamic acid (such as γDLPGA) polypeptides of S. epidermidis, or related staphylococci that express a γPGA polypeptide. The γPGA conjugates elicit an effective immune response against S. epidermidis, or other staphylococci, in subjects to which the conjugates are administered. A method of treating an infection caused by a Staphylococcus organism that expresses cap genes is also disclosed. The method can include selecting a subject who is at risk of or has been diagnosed with the infection by the Staphylococcus organism which expresses γPGA from the cap genes. Further, the expression of a γPGA polypeptide by the organism can then be altered. |
申请公布号 |
US8921071(B2) |
申请公布日期 |
2014.12.30 |
申请号 |
US201314058610 |
申请日期 |
2013.10.21 |
申请人 |
The United States of America as represented by the Secretary of the Department of Health and Human Services |
发明人 |
Otto Michael;Kocianova Stanislava |
分类号 |
A61K39/00;A61K39/085;C07K16/12;C12P21/02 |
主分类号 |
A61K39/00 |
代理机构 |
Klarquist Sparkman, LLP |
代理人 |
Klarquist Sparkman, LLP |
主权项 |
1. A method of producing poly-γ-glutamic acid (γPGA), comprising:
culturing one or more strains of S. warneri, S. saccharolyticus, S. caprae, S. hominis, S. haemolyticus or a combination thereof under conditions sufficient for producing γPGA; and purifying γPGA from the culture thereby producing γPGA. |
地址 |
Wasington DC US |