发明名称 |
Pharmaceutical composition, substrate comprising a pharmaceutical composition, and use of a pharmaceutical composition |
摘要 |
The invention relates to the use of a pharmaceutical composition for the local treatment or prevention of a tissue infection at an infection site, the pharmaceutical composition comprising at least two different antibiotics of group A or pharmaceutically acceptable derivatives thereof, or an antibiotic of group A and at least one antibiotic of group B or pharmaceutically acceptable derivatives thereof. Group A comprises primarily intracellular active antibiotics working as inhibitor of bacterial RNA polymerase; as inhibitor of gyrase; or as inhibitor of bacterial protein synthesis. Group B comprises primarily extracellular active antibiotics working as inhibitor of bacterial cell wall synthesis; or inhibitor of bacterial protein synthesis; or by direct destabilization or rupture of the bacterial cell wall.;The invention further relates to a pharmaceutical composition for treatment of extracellular and/or intracellular microbial infected cells and/or for the prevention of microbial cell infections comprising at least one antibiotic acting as an inhibitor of bacterial RNA polymerase and/or at least one antibiotic affecting the bacterial cell wall or its synthesis, and a substrate carrying a pharmaceutical composition.;The invention also relates to the use of a combination of at least one antibiotic acting as an inhibitor of bacterial RNA polymerase and at least one antibiotic affecting the bacterial cell wall or its synthesis as anti-adhesive against microorganisms on surfaces. |
申请公布号 |
US8921365(B2) |
申请公布日期 |
2014.12.30 |
申请号 |
US200812670354 |
申请日期 |
2008.07.23 |
申请人 |
Biomet Deutschland GmbH |
发明人 |
Duewelhenke Nicole |
分类号 |
A01N43/58;A61K31/50;A01N43/08;A61K31/34;A61K31/4709;A61K31/65;A61K38/12;A61K31/7088;A61K45/06;A61L31/16;A61L27/54;A61K31/665;A61K31/7048 |
主分类号 |
A01N43/58 |
代理机构 |
Harness, Dickey |
代理人 |
Harness, Dickey |
主权项 |
1. A method for local prevention of a tissue infection associated with gram-positive bacteria at the site of implantation of a prosthesis, occurring due to a surgical operation related to the implantation of the prosthesis, the method comprising implanting the prosthesis wherein the prosthesis is coated with a pharmaceutical composition consisting of a rifampin and fosfomycin or rifampin and daptomycin. |
地址 |
Berlin DE |