发明名称 |
NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE |
摘要 |
The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation and analyzing the conjugation using 2D NMR analysis. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst. |
申请公布号 |
SG11201407597X(A) |
申请公布日期 |
2014.12.30 |
申请号 |
SGX11201407597 |
申请日期 |
2013.05.16 |
申请人 |
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE SA |
发明人 |
SIEKMANN, JUERGEN;HAIDER, STEFAN;ROTTENSTEINER, HANSPETER;TURECEK, PETER |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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