QUINAZOLINONE DERIVATIVES AS HCV INHIBITORS

摘要

Inhibitors of HCV replication of formula (I) including stereochemically isomeric forms, salts, and solvates thereof, wherein R and R′ have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.;

主权项

1. A compound of Formula I or a stereoisomer thereof, wherein: at least one of  independently is selected from a group comprising  and the other  is selected from the group additionally comprising R and R′ are independently selected from —CR1R2R3, aryl optionally substituted with 1 or 2 substituents selected from halo and methyl, or heterocycloalkyl, wherein
R1 is selected from C1-4alkyl; C2-4alkyl substituted with methoxy or hydroxyl; and phenyl optionally substituted with 1 or 2 substituents independently selected from halo and methyl;R2 is hydroxyl, amino, mono- or di-C1-4alkylamino, C1-4alkyl-carbonylamino, C1-4alkyloxycarbonylamino;R3 is hydrogen or C1-4alkyl; or a pharmaceutically acceptable salts or a solvate thereof.