BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS

摘要

The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on baclofen and acamprosate combination.

主权项

1. A method of treating Alzheimer's disease or a related disease selected from senile dementia of AD type (SDAT), frontotemporal dementia (FTD), mild cognitive impairment (MCI) and age-associated memory impairment (AAMI), comprising administering to a subject in need thereof a combination of baclofen and acamprosate, or pharmaceutically acceptable salts thereof, in an amount effective to treat said subject.