| 发明名称 |
COLLATERAL GENE INACTIVATION BIOMARKERS AND TARGETS FOR CANCER THERAPY |
| 摘要 |
Methods for treating a subject determined to have a cancer comprising a heterozygous inactivation of a housekeeping gene (or a homozygous deletion of a functionally redundant housekeeping gene) by treating the subject with an inhibitor of the gene. For example, a subject having a cancer with an ENO gene deletion can be treated with a glycolysis inhibitor, such as an enolase inhibitor. In some aspects, a subject having a cancer with an ARS gene deletion can be treated with an ARS inhibitor. |
| 申请公布号 |
US2014378529(A1) |
申请公布日期 |
2014.12.25 |
| 申请号 |
US201214365367 |
申请日期 |
2012.12.14 |
| 申请人 |
Board Regents, The University of Texas System ;Dana-Farber Cancer Institute, Inc. |
发明人 |
Muller Florian L.;Fletcher-Sananikone Eliot;Colla Simona;Aquilanti Elisa;DePinho Ronald |
| 分类号 |
A61K31/713;A61K31/662;G01N33/50;C12Q1/68;A61K31/661;A61K45/06;C12N15/113;A61K31/5685 |
主分类号 |
A61K31/713 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition for use in treating a cancer in a subject, wherein the cancer has a homozygous deletion in a housekeeping gene and the housekeeping gene has a functionally redundant homologue, the composition comprising an inhibitor of the redundant homologue in an amount sufficient to inhibit the activity of the redundant homologue. |
| 地址 |
Austin TX US |
