| 主权项 |
1. A method of treating a cancer selected from breast cancer, ovarian cancer, lung cancer, liver cancer, and a sarcoma in a subject, the method comprising administering an effective amount of a compound of Formula I or pharmaceutically acceptable salt thereof, wherein: Ring A is a 3-8 membered aryl, heteroaryl, heterocyclic or alicyclic group; X is CH or N; Y is CH or N—R4 where R4 is H or C1-6 alkyl; L is —[C(R5)(R6)]q—, where each of R5 and R6 is, independently, H or C1-6 alkyl, wherein q is 0-4; each of R1 and R3 is, independently, halo, cyano, optionally substituted C1-6 alkoxy, hydroxy, oxo, amino, amido, alkyl urea, optionally substituted C1-6 alkyl, optionally substituted C1-6 heterocyclyl; two R2 are halo and two R2 are C1-6 alkoxy; m is 0-3; n is 4; p is 0-2; and Warhead is selected from the group consisting ofwherein X is halo, or triflate; and each of Ra, Rb, and Rc is, independently, H, substituted or unsubstituted C1-4 alkyl, substituted or unsubstituted C1-4 cycloalkyl, or cyano, to thereby treat the cancer. |
