Ophthalmic Lipophilic and Hydrophilic Drug Delivery Vehicle Formulations

摘要

The ophthalmic drug delivery vehicles provide comfort and compliance; drug solubility, residence time and permeability; and reduce side effects. In addition, the delivery vehicle can be slightly modified to provide an artificial tear formulation.

主权项

1. An ophthalmic drug delivery composition comprising from about 1% to about 15% w/v nonionic surfactant, one or more non-Newtonian high blend viscosity enhancing, non-gelling agents and from about 0.025% to about 0.90% sodium chloride, such that:
i. final composition viscosity at shear rates representative of a non-blinking eye is between 50 and 100 cps; ii. final composition viscosity at shear rates representative of a blinking eye of less than 30 cps but remaining above 5 cps, even after 30% dilution; and iii. a final composition ratio of i./ii. of 3:1 or greater,wherein w/v denotes weight by volume.