Apparatus for Separating Particles Utilizing Engineered Acoustic Contrast Capture Particles

摘要

An apparatus for separating particles from a medium includes a capillary defining a flow path therein that is in fluid communication with a medium source. The medium source includes engineered acoustic contrast capture particle having a predetermined acoustic contrast. The apparatus includes a vibration generator that is operable to produce at least one acoustic field within the flow path. The acoustic field produces a force potential minima for positive acoustic contrast particles and a force potential minima for negative acoustic contrast particles in the flow path and drives the engineered acoustic contrast capture particles to either the force potential minima for positive acoustic contrast particles or the force potential minima for negative acoustic contrast particles.

主权项

1. An apparatus for separating particles from a medium, comprising:
a capillary defining a flow path therein, said flow path in fluid communication with a medium source, said medium source including engineered acoustic contrast capture particles, at least some of the engineered acoustic contrast capture particles being configured to bind to a predetermined bioparticle and having an acoustic contrast that differs from the acoustic contrast of the predetermined bioparticle; and a vibration generator configured to produce at least one acoustic field within said flow path, said at least one acoustic field being configured to drive said engineered acoustic contrast capture particles to one or more a force potential minima.