| 发明名称 |
CLEAVAGE INHIBITORS OF TRANSFORMING GROWTH FACTOR BETA TYPE I RECEPTOR AND USES THEREOF IN CANCER THERAPY |
| 摘要 |
Disclosed herein are methods to inhibit cleavage of a type I receptor of transforming growth factor beta (TβRI) and reduce cancer cell invasiveness/metastasis, and agents and pharmaceutical compositions for use in these methods. Also disclosed herein are methods for identifying agents that inhibit cleavage of TβRI and methods for diagnosing and/or prognosing cancer based on nuclear localization of a intracellular domain of TβRI, which is a product of TβRI cleavage. |
| 申请公布号 |
US2014377268(A9) |
申请公布日期 |
2014.12.25 |
| 申请号 |
US201214004490 |
申请日期 |
2012.03.13 |
| 申请人 |
Landstrom Marene Inga-Britt;Mu Yabing;Sundar Reshma;Thakur Noopur;Gudey Shyam Kumar;Ekman Maria;Heldin Carl-Henrik |
发明人 |
Landstrom Marene Inga-Britt;Mu Yabing;Sundar Reshma;Thakur Noopur;Gudey Shyam Kumar;Ekman Maria;Heldin Carl-Henrik |
| 分类号 |
C07K16/28;C12Q1/68 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated antibody that binds to a type I receptor of transforming growth factor beta (TβRI) and blocks its cleavage. |
| 地址 |
Alunda SE |
