发明名称 |
MUTATED ANTHRAX TOXIN PROTECTIVE ANTIGEN PROTEINS THAT SPECIFICALLY TARGET CELLS CONTAINING HIGH AMOUNTS OF CELL-SURFACE METALLOPROTEINASES OR PLASMINOGEN ACTIVATOR RECEPTORS |
摘要 |
The present invention provides methods of specifically targeting compounds to cells overexpressing matrix metalloproteinases, plasminogen activators, or plasminogen activator receptors, by administering a compound and a mutant protective antigen protein comprising a matrix metalloproteinase or a plasminogen activator-recognized cleavage site in place of the native protective antigen furin-recognized cleavage site, wherein the mutant protective antigen is cleaved by a matrix metalloproteinase or a plasminogen activator overexpressed by the cell, thereby translocating into the cell a compound comprising a lethal factor polypeptide comprising a protective antigen binding site. |
申请公布号 |
US2014378654(A1) |
申请公布日期 |
2014.12.25 |
申请号 |
US201414313575 |
申请日期 |
2014.06.24 |
申请人 |
Government of the United States of America as Represented by the Secretary of |
发明人 |
LEPPLA Stephen H.;LIU Shi-Hui;NETZEL-ARNETT Sarah;BIRKEDAL-HANSEN Henning;BUGGE Thomas |
分类号 |
C07K7/06 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
1. An isolated mutant protective antigen protein comprising a matrix metalloproteinase-recognized cleavage site in place of the native protective antigen furin-recognized cleavage site, wherein the mutant protective antigen is cleaved by a matrix metalloproteinase. |
地址 |
Rockville MD US |