| 摘要 |
<p>Disclosed is an antitumor agent which has higher antitumor activity than conventional antitumor agents, while having low toxicity. Specifically disclosed is an antitumor agent which is characterized by containing a phosphine transition metal complex that is represented by general formula (1). In general formula (1), it is preferable that the phosphine ligand is an (S,S)-2,3-bisphosphinoquinoxaline derivative. It is particularly preferable that the phosphine ligand is an (S,S)-2,3-bis(tert-butylmethylphosphino)quinoxaline. (In the formula, R1 and R2 each represents a linear or branched alkyl group, a cycloalkyl group, a cycloalkyl group having a substituent, an adamantyl group, a phenyl group or a phenyl group having a substituent and has 1-10 carbon atoms; R1 and R2 are different from each other, and R1 has a higher priority than R2 as ranked in accordance with the RS system; R3 and R4 each represents a hydrogen atom, or a linear or branched alkyl group and has 1-6 carbon atoms; R3 and R4 may be the same groups or different groups; R3 and R4 may combine together to form a saturated or unsaturated ring, and the saturated or unsaturated ring may have a substituent; M represents a transition metal atom that is selected from the group consisting of gold, copper and silver; and X- represents an anion.)</p> |
