发明名称 |
AGONISTS OF DDAH1 FOR TREATING ENDOTHELIAL DYSFUNCTION |
摘要 |
The present invention derives from the finding that expression of DDAH1 is heavily post- transcriptionally regulated by microRNAs. By preventing or blocking the interaction between such microRNAs and the DDAH1 mRNA, the production of DDAH1 protein can be increased. This has utility in the prevention or treatment of diseases and disorders that are associated with reduced DDAH1 levels or increased ADMA levels, such as diseases or disorders that are characterised by endothelial dysfunction. |
申请公布号 |
WO2014202973(A1) |
申请公布日期 |
2014.12.24 |
申请号 |
WO2014GB51867 |
申请日期 |
2014.06.17 |
申请人 |
UCL BUSINESS PLC |
发明人 |
MOOKERJEE, RAJESHWAR;MEHTA, GAUTAM |
分类号 |
A61K31/713;A61P9/10;A61P9/12;C12N15/113;C12Q1/68 |
主分类号 |
A61K31/713 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|