发明名称 Compositions and methods for cytoprotection
摘要 The present invention provides compositions and methods for cytoprotection. In particular, it provides zinc chelate compositions comprising at least one zinc ion and at least one aminothiol ligand.
申请公布号 US8916712(B2) 申请公布日期 2014.12.23
申请号 US201414174669 申请日期 2014.02.06
申请人 The Board of Trustees of the University of Arkansas 发明人 Basnakian Alexei G.;Walker Richard B.;Sorenson John R. J.
分类号 C07F3/06;C07C323/58;C07C323/25;C07D207/16;C07D277/06;C07C323/59;C07D277/14 主分类号 C07F3/06
代理机构 Polsinelli PC 代理人 Polsinelli PC
主权项 1. A zinc chelate compound comprising at least one Zn ion and at least one ligand comprising Formula (II):wherein: R1′ and R2′ are independently selected from the group consisting of hydrogen, hydrocarbyl, and substituted hydrocarbyl, or together R1′ and R2′ form a group selected from the group consisting of ═O, ═S, and a hydrocarbyl ring comprising from three to six members; and R3′ and R4′ are independently selected from the group consisting of hydrogen, alkyl other than propyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or together R3′ and R4′ form a group selected from the group consisting of ═S and a hydrocarbyl ring comprising from three to six members; provided, however, that at least one of R1′, R2′, R3′ and R4′ is other than hydrogen.
地址 Little Rock AR US