发明名称 Method for producing tetrazole-substituted anthranilic acid diamide derivatives by reacting pyrazolic acids with anthranilic acid esters
摘要 The present invention relates to a process for preparing tetrazole-substituted anthranilic acid diamide derivatives of the formula (I); in which R1, R2, R3, R4, Q and Z have the meanings given in the description, by reacting pyrazole acids with anthranilic esters.
申请公布号 US8916710(B2) 申请公布日期 2014.12.23
申请号 US201214131147 申请日期 2012.07.05
申请人 Bayer Intellectual Property GmbH 发明人 Pazenok Sergii;Volz Frank;Lui Norbert;Neeff Arnd;Szywalski Sylvia
分类号 C07D401/14;C07D403/06 主分类号 C07D401/14
代理机构 Miles and Stockbridge 代理人 Miles and Stockbridge
主权项 1. A process for preparing a compound of formula (I) in which R1, R3 independently of one another represent hydrogen, or represent C1-C6-alkyl, C1-C6-alkoxy, C2-C6-alkenyl, C2-C6-alkynyl or C3-C6-cycloalkyl which are each optionally mono- or polysubstituted by identical or different halogen or nitro substituents, R2 represents C1-C6-alkyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, C1-C6-halocycloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-alkylsulphinyl, C1-C4-alkylsulphonyl, C1-C4-haloalkylthio, C1-C4-haloalkylsulphinyl, C1-C4-haloalkylsulphonyl, halogen, cyano, nitro, alkylamino, dialkylamino, cycloalkylamino or C3-C6-trialkylsilyl, R4 represents hydrogen, halogen, cyano, nitro, C1-C4-alkyl, C1-C4-haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C1-C4-alkoxy, C1-C4-haloalkoxy, SF5, C1-C4-alkylthio, C1-C4-alkylsulphinyl, C1-C4-alkylsulphonyl, C1-C4-haloalkylthio, C1-C4-haloalkylsulphinyl, C1-C4-haloalkylsulphonyl, C1-C4-alkylamino, di-(C1-C4-alkyl)amino, C3-C6-cycloalkylamino, (C1-C4-alkoxy)imino, (C1-C4-alkyl)(C1-C4-alkoxy)imino, (C1-C4-haloalkyl)(C1-C4-cyano, nitro, alkoxy)imino or C3-C6-trialkylsilyl, Q represents a tetrazole ring which is monosubstituted by R5, R5 represents C1-C5-alkyl which may be mono- to trisubstituted by halogen, Z represents CH or N, Wherein the compound of formula (I) furthermore may also comprise an N-oxide and/or a salt, comprising reacting a tetrazole-substituted pyrazole acid of formula (II) with an anthranilic ester of formula (III) in which R represents alkyl, cycloalkyl, alkoxyalkyl, arylalkyl, thioalkyl, alkylthioalkyl, alkylsulphonylalkyl, cyanoalkyl, haloalkyl, nitroalkyl or aryl, to give a compound of formula (IV) and reacting said compound of formula (IV) with an amine of general formula (V) R1NH2  (V) to give an anthranilamide of formula (I).
地址 Monheim am Rhein DE