| 发明名称 | Analogs of pituitary adenylate cyclase-activating polypeptide (PACAP) and methods for their use | ||
| 摘要 | This invention relates to novel analogs of pituitary adenylate cyclase-activating polypeptide (PACAP), which are agonists for the PACAP/vasoactive intestinal peptide (VIP) receptors: PAC1, VPAC1 and VPAC2 receptors. These PACAP analogs can be used as prophylactic/therapeutic agents for a wide range of medical disorders, including (but not limited to) cancer and autoimmune disease. These PACAP analogs can be coupled to suitable radionuclides and used in the localization, diagnosis and treatment of disseminated cancers and metastatic tumors, or coupled to small molecule therapeutics and used as vectors for targeted drug delivery. This invention also provides pharmaceutical compositions of one or more PACAP-like compounds of the invention either alone or in combination with one or more other prophylactic/therapeutic agents. | ||
| 申请公布号 | US8916517(B2) | 申请公布日期 | 2014.12.23 |
| 申请号 | US201013505370 | 申请日期 | 2010.11.02 |
| 申请人 | The Administrators of the Tulane Educational Fund | 发明人 | Coy David H.;Maderdrut Jerome L.;Li Min |
| 分类号 | A61K38/17;C07K14/435;A61P11/00;A61P13/12;A61P1/00;A61P27/02;A61P37/06;A61P9/00;A61P9/12;A61P35/00;A61P3/04;A61P3/10;A61K45/06;C07K14/575;A61K33/24;A61K38/00 | 主分类号 | A61K38/17 |
| 代理机构 | Clark & Elbing LLP | 代理人 | Clark & Elbing LLP ;Clark, Esq. Paul T.;Armstrong Todd |
| 主权项 | 1. A compound having a sequence selected from any one of SEQ ID NOs: 4-13 or a pharmaceutically acceptable salt thereof. | ||
| 地址 | New Orleans LA US | ||