发明名称 |
<i>Leishmania </i>sterol 24-c-methyltransferase compositions for the prevention, treatment and diagnosis of leishmaniasis |
摘要 |
Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise Leishmania sterol 24-c-methyltransferase (SMT) polypeptides, portions, variants and/or fusions, as well as polynucleotides encoding SMT polypeptides, portions, variants and/or fusions. |
申请公布号 |
US8916168(B2) |
申请公布日期 |
2014.12.23 |
申请号 |
US200812171729 |
申请日期 |
2008.07.11 |
申请人 |
Infectious Disease Research Institute |
发明人 |
Reed Steven;Goto Yasuyuki |
分类号 |
A61K39/008;C07H21/04;A61K38/45;A61K39/00 |
主分类号 |
A61K39/008 |
代理机构 |
Merial Limited |
代理人 |
Jarecki-Black Judy;Kitchen Chad;Merial Limited |
主权项 |
1. A vaccine composition comprising a fusion polypeptide and an immunostimulant, wherein the fusion polypeptide comprises a first polypeptide and a second polypeptide, wherein the second polypeptide is heterologous fusion partner as to the first polypeptide, wherein the first polypeptide comprises a recombinant Leishmania sterol 24-c-methyltransferase (SMT) polypeptide comprising an amino acid sequence of SEQ ID NO:1, or a sequence having at least 95% identity to the amino acid sequence of SEQ ID NO:1, and the immunostimulant comprises a synthetic CpG unmethylated dinucleotide (CpG-containing oligonucleotide), a synthetic lipid A, monophosphoryl lipid (MPL) adjuvant, 3-de-O-acylated monophosphoryl lipid A (3D-MPL) adjuvant, an aminoalkyl glucosaminide 4-phosphates (AGP), a synthetic Toll-like receptor agonist or a combination thereof and the fusion polypeptide and the immunostimulant are present in amounts effective to induce an immune response. |
地址 |
Seattle WA US |