C-Terminally Tethered Amino Acids and Their Fibrinolytic Therapeutic Uses

摘要

The present disclosure provides a C-terminal tethered amino acid for modulating the thrombolytic, fibrinolytic and/or anticoagulant properties of a coagulation protein. The present disclosure also provides a coagulation protein having a catalytic site modified, either at the histidine or serine residue, with the C-terminal tethered amino acid as well as therapeutic applications of those modified coagulation proteins.

主权项

1. A compound of formulawherein,
(aa) is any amino acid less the amino group forming the amide linkage; PEG is 2-8 linear repeating units having the following formulawherein each carbon atom of said unit is optionally substituted; and
Y is