发明名称 |
COMPOSITIONS AND METHODS FOR ENHANCED GENERATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS |
摘要 |
The present invention relates to methods, kits and compositions for expansion of hematopoietic stem/progenitor cells and providing hematopoietic function to human patients in need thereof. In one aspect, it relates to kits and compositions comprising a Notch agonist and an aryl hydrocarbon receptor antagonist. Also provided herein are methods for expanding the hematopoietic stem/progenitor cells using kits and compositions comprising a Notch agonist and an aryl hydrocarbon receptor antagonist. The hematopoietic stem/progenitor cells expanded using the disclosed kits, compositions and methods include human umbilical cord blood stem/progenitor cells, placental cord blood stem/progenitor cells and peripheral blood stem cells. The present invention also relates to administering hematopoietic stem/progenitor cells expanded using a combination of a Notch agonist and an aryl hydrocarbon receptor antagonist to a patient for short-term and/or long-term in vivo repopulation benefits. |
申请公布号 |
US2014369973(A1) |
申请公布日期 |
2014.12.18 |
申请号 |
US201214363748 |
申请日期 |
2012.12.07 |
申请人 |
FRED HUTCHINSON CANCER RESEARCH CENTER ;NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC. DBA THE GENOMICS INSTITUTE OF THE NORVATIS ;RESEARCH FOUNDATION (GNF) |
发明人 |
Bernstein Irwin D.;Boitano Anthony E.;Cooke Michael |
分类号 |
C12N5/0789;A61K35/28 |
主分类号 |
C12N5/0789 |
代理机构 |
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代理人 |
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主权项 |
1. A method of expanding hematopoietic stem/progenitor cells, comprising culturing isolated hematopoietic stem/progenitor cells ex vivo in the presence of a composition comprising a Notch agonist and an aryl hydrocarbon receptor antagonist, thereby producing an expanded hematopoietic stem/progenitor cell sample. |
地址 |
Seattle WA US |