Method of treating diabetic peripheral neuropathy through amendment of pre-neuronal diabetic coagulative micro-angiopathy and neuronal deficiency of mitochondrial ATP production, and through induction of neuronal regeneration

摘要

DPN is an intractable and tormenting neurovascular and dermal disorder.;Two patients of DPN of stocking-glove pattern were treated with SAG for treatment of microvascuar coagulopathy, induction of vasodilation and possible induction of angioneogenesis; with ALC for ATP generation through mitochondrial beta-oxidation of fats; and with ALA for antioxidative stress to prevent precipitation of vascular damage and to prevent DPN recurrence. SAG+ALC was to cure maceration.;Thus, SAG+ALC+ALA was effective in mitigating and curing their distresses. It shall be one of the logical and practical means of prompt DPN therapy not only to alleviate DPN but also to lead to “cure.”

主权项

1. A method of treating diabetic neuropathy, including a first stage of treatment with sarpogrelate (SAG) for a period of time, a second stage of treatment with SAG and acetyl-L-carnitine (ALC) for a period of time; and a third stage of treatment with ALC and epalrestat (EPR) for a period of time.