CATALYTIC NUCLEIC ACID AND GOLD NANOPARTICLES FOR DETECTION OF BIOMOLECULES

摘要

The present invention relates to catalytic nucleic acid molecule signal amplification combined with surface plasmon properties of gold nanoparticles to achieve simple and sensitive colorimetric detection of biological targets. The assays of the present invention have about 50 pM sensitivity without the need for purification steps, can detect multiple targets in parallel, and is easily adaptable to new targets. Themethods of the present inventionare capable of rapid detection of genetic targets for gonorrhea, syphilis, malaria, and hepatitis B infections.