发明名称 |
POLYCATION-FUNCTIONALIZED NANOPOROUS SILICON CARRIER FOR SYSTEMIC DELIVERY OF GENE SILENCING AGENTS |
摘要 |
Disclosed are methods and compositions containing functionalized nanoporous silicon particles, useful in a variety of diagnostic and/or therapeutic regimens for delivery of genetic constructs to one or more cells, tissues, and/or organs of interest. Also provided are methods for introducing into selected host cells one or more selected nucleic acid molecules. The present disclosure is also directed to a method of treating a tumor, comprising the step of administering to an individual one or more of the compositions and formulations thereof as described herein. |
申请公布号 |
WO2014201276(A1) |
申请公布日期 |
2014.12.18 |
申请号 |
WO2014US42166 |
申请日期 |
2014.06.12 |
申请人 |
THE METHODIST HOSPITAL |
发明人 |
SHEN, HAIFA;FERRARI, MAURO;SHEN, JIAN;ZHANG, MINGZHEN |
分类号 |
A61K9/16;A61K39/395;A61K47/30;A61K47/36 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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